About the DREAM trial

About Sickle Cell Disease

Have questions? Contact the Clinical Trial Information Center at DREAMstudy@gbt.com




About Sickle Cell Disease


Overview
Symptoms & Treatment


Sickle cell disease (SCD) is a group of red blood cell disorders, where the red blood cells can change shape—from healthy, round, bendable cells to stiff, sticky, crescent shaped cells that die early and can easily get stuck and block healthy blood flow in the body. Sickle cell disease is not contagious. It is a genetic condition that is present at birth and is passed down from both parents.

STATS

It is estimated that:

100K

Americans affected
by SCD

1 in 365

Black or African-American babies are born with SCD

1 in 16K

Hispanic-American babies are born with SCD

~20%

of people living with SCD usually receive their care in an emergency room

SDC is a genetic, hereditary disease

Treatment can help, but this condition cannot be cured

Requires medical diagnosis

Lab tests or imaging always required

Chronic: lifelong

For informational purposes only. Consult your local medical authority for advice.
Content ources:  National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention

SYMPTOMS

Pain areas: in the joints

Pain types: can be sudden in the chest, can include vaso-occlusive crises (VOCs)

Whole body: dizziness, fatigue, low oxygen in the body, or malaise

Urinary: inability to make concentrated or dilute urine or blood in urine

Also common: abnormal breakdown of red blood cells, delayed development, inflamed fingers or toes, pallor, shortness of breath, or yellow skin and eyes

TREATMENT

Management of sickle cell is usually aimed at avoiding pain episodes, like VOCs, relieving symptoms and preventing complications. Treatments might include medications and blood transfusions. Vaccinations and penicillin can be used to help prevent life-threatening infections.

For informational purposes only. Consult your local medical authority for advice. Content source: Mayo Clinic

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